Henry Binder

Department: 
Internal Medicine
Biography: 

B.A. 1957, Dartmouth College

M.D. 1961, New York University

Postdoctoral Fellow, Yale University School of Medicine

Intern/Resident, Bellevue Hospital, New York University

Dr. Binder’s research career has primarily been directed toward the regulation of colonic electrolyte transport and the pathophysiology of diarrhea and the basis for development of new approaches for treatment of diarrhea. These transport studies were primarily in vitro and dissected the cellular mechanisms of Na, C1, K, HCO3 and short-chain fatty acid transport and were supported by NIDDK for 37 years. During the past few years, Dr. Binder has focused his investigative activities toward the establishment of a major modification of oral rehydration solution (ORS) that is based on his prior laboratory studies that demonstrated butyrate-stimulated Na absorption in the colon was cyclic AMP-insensitive. These studies supported by Bill & Melinda Gates Foundation are designed to increase the uptake of ORS with the adaption of an improved formulation with resistant starch (starch that is relatively insensitive to amylase digestion).

International Activity

World, Rehydration (2010) - Planning for the Delivery of a More Effective Oral Rehydration Solution to Improve Diarrhea Control Worldwide

Diarrhea and Oral Rehydration TherapyIndia (2008) - Development of a major modification of Oral Rehydration Solution (ORS) for the treatment of acute diarrhea.

Selected Recent Publications:

Radiation decreases murine small intestinal HCO3- secretion.
Zhang K, Yin L, Zhang M, Parker MD, Binder HJ, Salzman P, Zhang L, Okunieff P, Vidyasagar S. Radiation decreases murine small intestinal HCO3- secretion. International Journal Of Radiation Biology 2011, 87:878-88.
 
Identification of functionally distinct Na-HCO3 co-transporters in colon.
Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM. Identification of functionally distinct Na-HCO3 co-transporters in colon. PloS One 2013, 8:e62864.
 
Preventive strategy against infectious diarrhea–a holistic approach.
Motarjemi Y, Steffen R, Binder HJ. Preventive strategy against infectious diarrhea–a holistic approach. Gastroenterology 2012, 143:516-519.
 
Role of colonic short-chain fatty acid transport in diarrhea.
Binder HJ. Role of colonic short-chain fatty acid transport in diarrhea. Annual Review Of Physiology 2010, 72:297-313.